PRODUCT DETAILS

About Actipraz-DXR Capsule

DOMPERIDONE+ESOMEPRAZOLE belongs to a group of gastrointestinal agents used to treat acidity, heartburn, gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, nausea, vomiting, dyspepsia (indigestion), epigastric pain, peptic ulcers, and eradication of helicobacter pylori infection. DOMPERIDONE+ESOMEPRAZOLE is a sustained release formulation that prolongs drug release for a longer duration of time. 

DOMPERIDONE+ESOMEPRAZOLE is a combination of two drugs: Esomeprazole (proton pump inhibitor) and Domperidone (a dopamine antagonist). Esomeprazole works by blocking an enzyme called gastric proton pump, which is responsible for the production of acid Domperidone works by increasing the movements and contractions of stomach muscle. Together, DOMPERIDONE+ESOMEPRAZOLE helps in treating acidity-related problems.

Take DOMPERIDONE+ESOMEPRAZOLE 1 hour prior to food. Swallow DOMPERIDONE+ESOMEPRAZOLE as a whole with a glass of water; do not chew, or break the tablet. You are advised to take DOMPERIDONE+ESOMEPRAZOLE for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side effects such as dry mouth, stomach pain, diarrhea, headache, and flatulence. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Inform your doctor before taking DOMPERIDONE+ESOMEPRAZOLE if you have severe kidney or liver disease; if you are due to have Chromogranin A blood test; if you have fungal infections, heart problems, or HIV infection. Talk to your doctor before taking DOMPERIDONE+ESOMEPRAZOLE if you have osteoporosis: DOMPERIDONE+ESOMEPRAZOLE may increase the risk of bone fractures on long-term treatment. Consult your doctor before taking DOMPERIDONE+ESOMEPRAZOLE if you are pregnant or breastfeeding. DOMPERIDONE+ESOMEPRAZOLE may cause dizziness, so drive only if you are alert. DOMPERIDONE+ESOMEPRAZOLE should not be given to children as safety has not been established. Avoid consuming alcohol and DOMPERIDONE+ESOMEPRAZOLE as it could lead to increased drowsiness and elevate stomach acid production. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Actipraz-DXR Capsule

Acidity, Heartburn, Gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome

Medicinal Benefits of Actipraz-DXR Capsule

DOMPERIDONE+ESOMEPRAZOLE is a combination of two drugs: Esomeprazole and Domperidone (SR) - in sustained-release form. DOMPERIDONE+ESOMEPRAZOLE is used to treat acidity, heartburn, gastro-oesophageal reflux disease (GERD), Zollinger-Ellison syndrome, nausea, vomiting, dyspepsia (indigestion), epigastric pain, peptic ulcers, and eradication of helicobacter pylori infection. Esomeprazole is a proton pump inhibitor that blocks an enzyme called gastric proton pump, responsible for acid production. Domperidone is a dopamine antagonist which works by increasing the movements and contractions of stomach muscles. Together, DOMPERIDONE+ESOMEPRAZOLE helps in treating acidity-related problems. DOMPERIDONE+ESOMEPRAZOLE is a sustained release formulation effective for a longer duration of time.

Directions for Use

Take DOMPERIDONE+ESOMEPRAZOLE 1 hour prior to food. Swallow DOMPERIDONE+ESOMEPRAZOLE as a whole with a glass of water; do not chew, or crush the tablet. Depending on your medical condition, your doctor will decide how long you need to take DOMPERIDONE+ESOMEPRAZOLE.

Side Effects of Actipraz-DXR Capsule

• Dry mouth
• Stomach pain
• Diarrhea
• Headache
• Flatulence

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Do not take DOMPERIDONE+ESOMEPRAZOLE if you are allergic to any of its contents or other proton pump inhibitors (such as pantoprazole, rabeprazole, lansoprazole or omeprazole); if you are taking nelfinavir (used to treat HIV); if you have prolactinoma (tumour of the pituitary gland), blockage in intestines, bleeding in stomach or intestine, moderate to severe liver disease, low level of potassium or magnesium or high levels of magnesium, and heart problems. Inform your doctor before taking DOMPERIDONE+ESOMEPRAZOLE if you have severe kidney, heart or liver disease, or if you are due to have Chromogranin A blood test; if you have fungal infections, heart problems or HIV infection. Talk to your doctor if you experience weight loss, problems with swallowing, stomach pain, indigestion, vomiting food or blood, or if you pass black stools while taking DOMPERIDONE+ESOMEPRAZOLE. On long-term treatment, DOMPERIDONE+ESOMEPRAZOLE may cause low magnesium levels, and vitamin B12 levels, and increase the risk of bone fractures; the doctor may advise regular tests for monitoring your condition. Do not take DOMPERIDONE+ESOMEPRAZOLE if you are pregnant or breastfeeding unless prescribed by the doctor. DOMPERIDONE+ESOMEPRAZOLE may cause dizziness, so drive only if you are alert. DOMPERIDONE+ESOMEPRAZOLE should not be given to children as safety has not been established. Avoid consuming alcohol along with DOMPERIDONE+ESOMEPRAZOLE as it could lead to increased drowsiness and can elevate the production of stomach acid. A prolonged intake of DOMPERIDONE+ESOMEPRAZOLE is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that does not improve, immediately consult a doctor. 

Drug Interactions

Drug-Drug Interaction:

DOMPERIDONE+ESOMEPRAZOLE may have interaction with anti-HIV (atazanavir, nelfinavir, saquinavir, ritonavir), blood thinner (clopidogrel, warfarin), anti-fungal (ketoconazole, itraconazole, voriconazole, fluconazole), anti-cancer (erlotinib, toremifene, vandetanib, vincamine), benzodiazepine (diazepam), anti-convulsant (phenytoin), anti-platelet (Cilostazol), antacid (cisapride, dolasetron, prucalopride), immunosuppressant (tacrolimus), anti-TB (rifampicin), antibiotics (Erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine), a drug used to treat hypothyroidism (levothyroxine), anti-rheumatoid (methotrexate), anti-depressant (citalopram, escitalopram), cardiac glycoside (digoxin), anti-malarial (halofantrine), anti-psychotic (haloperidol, pimozide, sertindole), anti-allergy ( equitation, mizolastine), anti-arrhythmic (amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol), anti-hypertensives (diltiazem, verapamil).

Drug-Disease Interaction:

DOMPERIDONE+ESOMEPRAZOLE may have interactions with Clostridium difficile-associated diarrhea (CDAD), liver disease, bone fractures, prolactinoma (tumor of the pituitary gland), blockage in the intestines, bleeding in the stomach or intestine, moderate to severe liver disease, low level of potassium or magnesium or high levels of magnesium, and heart problems.

Safety Advice

ALCOHOL

Avoid consumption of alcohol while taking DOMPERIDONE+ESOMEPRAZOLE. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

PREGNANCY

It is not recommended to take DOMPERIDONE+ESOMEPRAZOLE during pregnancy. Consult your doctor before taking DOMPERIDONE+ESOMEPRAZOLE if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

BREAST FEEDING

Consult your doctor before taking DOMPERIDONE+ESOMEPRAZOLE; your doctor will decide whether DOMPERIDONE+ESOMEPRAZOLE can be taken by breastfeeding mothers or not.

DRIVING

DOMPERIDONE+ESOMEPRAZOLE may cause dizziness. Do not drive or operate machinery unless you are alert.

LIVER

Dose adjustment may be needed. Consult your doctor before taking DOMPERIDONE+ESOMEPRAZOLE if you have a liver impairment or any concerns regarding this.

KIDNEY

Dose adjustment may be needed. Consult your doctor before taking DOMPERIDONE+ESOMEPRAZOLE if you have kidney impairment or any concerns regarding this.